ABOUT IISAGE.
We have established a Biology Integration Institute to determine how genome architecture, organismal biology, and phenotypic plasticity contribute to sex-specific aging and its evolution. In many species across the animal kingdom, one sex ages faster or has a longer lifespan. This sex-specific aging has significant implications for conservation, agriculture, and human health. However, no unified model exists that reveals how mechanistic and evolutionary processes cause the diverse patterns of sex-specific aging seen in nature. Furthermore, current research on sex-specific aging has been siloed because researchers primarily use discipline-specific approaches without integration.
IISAGE, or Integration Initiative: Sex, Aging, Genomics, and Evolution brings together expertise from evolutionary biology, molecular genetics, genomics, physiology, and computational biology to identify the molecular mechanisms generating sex differences in aging. Working with amniotes, fish, and insects, IISAGE will work toward defining the rules that govern sex-specific aging. Tightly integrated projects with common methodologies will test hypotheses focused on differences between the sexes in genome architecture, organismal biology, and phenotypic plasticity to understand sex-specific aging. Through an integrated, iterative process of data collection, modeling, and hypothesis testing, IISAGE will define how processes at the molecular, organismal, and population level interact to generate sex-specific aging and develop predictive models for how sex differences in aging arise.
INTELLECTUAL MERIT.
dimorphism, and novel sex chromosomes. Species that will be subjected to multi-population sampling and laboratory
experiments for further addressing IISAGE Themes are highlighted in purple. TSD: Temperature sex determination.
Sex differences in aging are common in many taxa but vary significantly, and the mechanisms that control them are not understood. Identifying rules that explain sex differences in aging is challenging because phenotypic sex is confounded with many other differences between males and females. IISAGE will determine how genome architecture, organismal biology, and phenotypic plasticity generate sex differences in aging and define evolutionarily conserved and taxon-specific mechanisms controlling sex differences in aging. By integrating across disciplines, approaches, and levels of biological organization, IISAGE will develop predictive models for how genome architecture, organismal biology, and phenotypic plasticity can interact and lead to sex-specific aging. IISAGE’s approach will include data from both wild species, laboratory manipulations, and citizen scientists to provide unprecedented insights into the mechanisms controlling sex differences in aging.
BROADER IMPACTS.
IISAGE will produce novel analysis tools and hundreds of matched datasets profiling expression and chromatin in dozens of species, providing new resources for the scientific community. In addition, the insights into sex differences in aging derived from IISAGE’s work will be of interest to scientists ranging from basic biologists to translational researchers and individuals in the medical and conservation fields.
IISAGE also contributes to STEM education through our Data Nuggets program, which consists of classroom activities co-created by high school teachers and IISAGE scientists. Additionally, we engage with the broader community through various outreach initiatives aimed at non-scientists.
CONNECT WITH US.
