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The Integration Initiative: Sex, Aging, Genomics, and Evolution (IISAGE) is an NSF-funded Biological Integration Institute aimed at understanding the functional genomic basis of differences in lifespan and aging between sexes across a wide range of animals. We are comprised of 11 research laboratories spread across 9 institutions.

Why do we study sex-specific aging?

There is immense variation in how females and males age in the animal kingdom. In humans, sex differences in aging are strong, with females living longer. In model organisms, we can study how sex differences are impacted by genetics and the environment, and how these factors influence distinct aging processes in females and males. By studying diverse species, we can better understand conserved mechanisms regulating sex-specific aging across the animal kingdom.


Upcoming Seminar

Aging in the open field: effects of environment, sex, and age on gene expression

Register here: https://shorturl.at/4RDJB


Stay Updated!

IISAGE is off to a strong start in 2025! Our team joined UAB's Biology Dept. at the SICB meeting, connecting with 150+ students and showcasing trainees' research to share IISAGE discoveries with the public! #SICB2025 #Research #IISAGE⚗️🧬

Integration Initiative: Sex, Aging, Genomics, and Evolution (@iisage.bsky.social) 2025-01-16T15:09:58.166Z

IISAGE hosted a workshop at the Plant and Animal Genome Conference (PAG) in San Diego, CA! The session, "Genomics and Epigenomics of Aging," highlighted recent breakthroughs in aging research across species. Big thanks to all the amazing speakers! #Genomics #AgingResearch #PAG2025

Integration Initiative: Sex, Aging, Genomics, and Evolution (@iisage.bsky.social) 2025-01-16T16:39:57.202Z

Special thanks to the National Science Foundation for providing the funding that enables our research.