There is immense variation in how females and males age in the animal kingdom. In humans, sex differences in aging are strong, with females living longer. In model animals, we can see how sex differences are impacted by environment and genetics. By studying different species, we can better understand how these factors influence the distinct aging processes in males and females.

The Integration Initiative: Sex, Aging, Genomics, and Evolution (IISAGE) focuses on how genome architecture, organismal biology, and phenotypic plasticity underpin sex-specific aging, and how it evolves. Established in 2022, our institute is comprised of eleven laboratories spread out over nine institutions nationwide. LEARN MORE

Special thanks to the National Science Foundation for providing the funding that enables our research.